PHILADELPHIA, US: It was previously believed that Streptococcus mutans was the main microorganism responsible for dental caries. However, in a recent study, researchers have discovered that another bacterial species, Selenomonas sputigena, plays a major role in dental caries development. The unique insights gained in the study could help in the development of new strategies for caries prevention.
In the study, the researchers analysed samples of plaque from the teeth of 300 children aged 3 to 5 years, half of whom had caries. They then validated their findings on a further set of 116 plaque samples from 3- to 5-year-olds. They found that, although S. sputigena does not cause caries on its own, S. sputigena interacts with S. mutans in a manner that enhances its cariogenic power.
“This was an unexpected finding that gives us new insights into the development of caries, highlights potential future targets for cavity prevention, and reveals novel mechanisms of bacterial biofilm formation that may be relevant in other clinical contexts,” said senior author Prof. Hyun Michel Koo, a founding director of the Center for Innovation and Precision Dentistry at the University of Pennsylvania School of Dental Medicine.
The researchers explained that S. mutans metabolises sugars to produce glucans to protect the biofilm bacteria and that S. sputigena can become trapped in the glucans. Once this occurs, S. sputigena grows rapidly, forming honeycomb-shaped superstructures that further encapsulate and protect S. mutans, thus increasing acid production within the plaque.
The study was a collaboration between the University of Pennsylvania School of Dental Medicine and the University of North Carolina at Chapel Hill Adams School of Dentistry and Gillings School of Global Public Health. “This was a perfect example of collaborative science that couldn’t have been done without the complementary expertise of many groups and individual investigators and trainees,” said co-author Prof. Kimon Divaris from the University of North Carolina at Chapel Hill.
The researchers are now planning to further investigate how S. sputigena ends up in the aerobic environment of the tooth surface. “This phenomenon in which a bacterium from one type of environment moves into a new environment and interacts with the bacteria living there, building these remarkable superstructures, should be of broad interest to microbiologists,” Prof. Koo concluded.
JENA, Germany: German scientists studying the skulls and teeth of pedigreed hairless dogs from the collection of the Friedrich Schiller University Jena’s ...
LOUISVILLE, Ky., US: Researchers from the US have recently examined the role that oral microbes play in regulating antiviral responses in the oral cavity. ...
GOLD COAST, Australia: High socio-economic status has often been linked to improved health outcomes. However, according to a global study of 30 countries, ...
HONG KONG, China/BERKELEY, Calif., US: A study led by researchers in China has recently examined the impact of the oral microbiota on overall health. The ...
GOTHENBURG, Sweden: Obesity is a medical concern that may lead to numerous health problems, including diabetes and cardiovascular disease. A recent study ...
PHILADELPHIA, U.S./CHENGDU, China: Despite significant advancements in oral health care, periodontitis remains the most common cause of tooth loss, as well ...
SEOUL, South Korea: According to the American Association of Orthodontists , more than five million people seek orthodontic treatments each year in the US ...
ALEXANDRIA, Va., U.S.: Protecting children against the early onset of dental caries is something all dentists should consider a priority. According to the ...
CALOOCAN, Philippines: According to the World Health Organization, 514 million children have caries of the primary dentition. Additionally, data from 2021 ...
Education
Live webinar Thu. 18 July 2024 8:00 pm EST (New York)
For decades, dentists around the world have profited from high demand for dental clinics by selling to a dental support organisation (DSO), entering ...
Aligner orthodontics is one of the fastest-growing areas of cosmetic dental treatment. To broadly assess patient satisfaction with aligner therapy, a team ...
Broken file management is one of the most challenging parts of endodontic treatment. Regardless of whether the clinician is faced with a retreatment ...
To post a reply please login or register